It’s been two and a half years since the Lost JuLai tragedy, which laid waste to an entire city and engulfed the whole planet in chaos. Meryl, now a senior journalist, continues her search for Vash with her new younger sidekick, Milly, and runs into Wolfwood along the way. As plant robberies begin taking place once again, they sense Millions Knives’s organization conspiring behind the scenes.
Meanwhile, Vash has taken the new name Eriks and is living in hiding in a backwater town when he gets an abrupt visit from Jessica, a young girl with an SOS from the third ship they call home. He thus decides to put an end to a long-standing feud in order to protect those dear to him.
Just as the pieces of the story begin falling back together again, the planet receives a message from the far reaches of outer space: “We are a fleet of colony ships from Earth... Those who wish may accompany us to a new frontier.” The entire population rejoices at this news. However, as if to mock their celebration, the one-winged angel returns to wreak havoc and despair. Fates collide to forge a final conclusion for the panicked planet.
